Blood: The Last Vampire is a 2000 anime film produced by Production I.G and SPE Visual Works and directed by Hiroyuki Kitakubo. The story is set in 1966. Its main protagonist is a girl named Saya, who hunts bat-like creatures called chiropterans. Saya is introduced on a subway train, where she assassinates a man in a suit. Her American contacts or handlers arrive. One of them, David, begins to brief Saya on another mission, while the other, Louis, discovers that the man Saya has just killed was probably not a chiropteran. Saya's next mission begins at the American Yokota Air Base, which is active in the buildup to the Vietnam War.